Dysplastic nevus - Nevus Displastiku
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Dysplastic nevi ― Bijopsija hija rakkomandata għall-Punent.
References
Dysplastic nevus , magħruf ukoll bħala nevus atipiku jew Clarks, qanqal dibattiti fid-dermatoloġija u d-dermatopatoloġija. It-tobba spiss jagħmlu bijopsija ta’ dawn il-moli minħabba li jistgħu jidhru anormali u jqajmu tħassib dwar il-melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , magħrufa wkoll bħala nevi atipiċi jew Clark, kultant jistgħu jwasslu għal melanoma. Madwar 36% tal-melanomi jinstabu ħdejn in-nevi displastiċi. Sinjali li nevus displastiku jista 'jinbidel f'melanoma jinkludu forma irregolari, aktar bidliet fil-pigment, jew kulur griż. Dawn il-kanċers normalment iseħħu f'età iżgħar (madwar nofs is-snin tletin) , jistgħu jkunu multipli, u ħafna drabi jkunu fuq it-tronk. Ġenetikament, dysplastic nevi huma bejn in-nevi beninni u l-melanoma. Madankollu, 20% sa 30% biss tal-melanomi ġejjin minn nevi eżistenti. Peress li l-biċċa l-kbira tan-nevi ma jsirux melanoma, normalment mhux rakkomandat li jitneħħew b'mod preventiv.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma hija tip ta’ tumur li jifforma meta l-melanoċiti, ċelloli responsabbli għall-kulur tal-ġilda, isiru kanċeroġeni. Melanoċiti joriġinaw mill-crest newrali. Dan ifisser li l-melanomi jistgħu jiżviluppaw mhux biss fuq il-ġilda iżda wkoll f'żoni oħra fejn iċ-ċelloli tal-crest newrali jemigraw, bħall-passaġġ gastrointestinali u l-moħħ. Ir-rata ta 'sopravivenza għal pazjenti b'melanoma fi stadju bikri (stadju 0) hija għolja għal 97%, filwaqt li tinżel b'mod sinifikanti għal madwar 10% għal dawk iddijanjostikati b'mard fi stadju avvanzat (stadju IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Riskju tal-kanċer
Kif jidher f'individwi Kawkasi fl-Istati Uniti, dawk b'nevi displastiċi għandhom riskju tul il-ħajja li jiżviluppaw melanoma ta 'aktar minn 10%. Min-naħa l-oħra, dawk mingħajr l-ebda nevus displastiku għandhom riskju li jiżviluppaw melanoma ta 'inqas minn 1%.
○ Prekawzjoni għal individwi b'nevi displastiki
L-awtoeżami tal-ġilda huwa ġeneralment rakkomandat għall-prevenzjoni tal-melanoma (billi jiġu identifikati nevi atipiċi li jistgħu jitneħħew) jew għal skoperta bikrija ta 'tumuri eżistenti. Nies bi storja personali jew familjari ta’ kanċer tal-ġilda jew ta’ nevi atipiċi multipli għandhom jaraw dermatologu mill-inqas darba fis-sena biex ikunu żguri li mhumiex qed jiżviluppaw melanoma.
L-abbrevjazzjoni [ABCDE] kienet utli biex tgħin lill-fornituri tal-kura tas-saħħa u lill-lajċi jiftakru l-karatteristiċi ewlenin ta' melanoma. Sfortunatament għall-persuna medja, ħafna keratoses seborrheic, xi lentigo senilis, u anke felul jista 'jkollhom karatteristiċi [ABCDE], u ma jistgħux jiġu distinti minn melanoma.
○ [ABCDE]
Asymmetrical: Leżjoni tal-ġilda asimmetrika.
Border: Il-bord tal-leżjoni huwa irregolari.
Color: melanomi normalment ikollhom kuluri irregolari multipli.
Diameter: in-nevi akbar minn 6 mm huma aktar probabbli li jkunu melanomi minn nevi iżgħar.
Evolution: L-evoluzzjoni (jiġifieri bidla) ta 'nevus jew leżjoni tista' tindika li l-leżjoni qed issir malinna.